Phenytoin Ikapharmindo Dosage/Direction for Use

Capsule: The dose given depends on the individual patient response and drug levels in blood.
The beginning should be given in divided doses (usually 2 times a day).
Adults: Initial dose of 300 mg in 2 divided doses. Maintenance dose is usually 300-400 mg or 3-5 mg/kg body weight per day (maximum 600 mg).
Children: Initial dose is 5 mg/kg body weight per day, divided in 2 doses, with recommended maintenance dose is 4-7 mg/kg body weight per day.
Injection: Intravenous administration rate should not exceed 50 mg per minute. Phenytoin sodium has a relatively narrow safety margin. The intravenous route is preferred in the treatment of status epilepticus, because of the delay in absorption in intramuscular administration.
Status Epilepticus: Intravenous administration: 150 to 250 mg injected slowly, followed by 100 to 150 mg if necessary 30 minutes afterwards. Higher doses may be required to control seizures. Dosage for children is usually determined in accordance with bodyweight taking 150 lbs as the weight of an adult. The pediatric dose may also be calculated based on 250 mg per square meter of body surface. When the patient's extremities are completely immobilised by convulsions or the veins are inaccessible, medication can be administered intramuscularly during the attack. If Phenytoin does not terminate the seizures, use other anti-convulsants, intravenous barbiturates, general anesthesia, or other measures may be considered.
Neurosurgery: Prophylactic dosage of 100 to 200 mg (2 to 4 ml) intramuscularly at about 4 hour intervals during surgery and to be continued during the post-operative period.